The basic pharmacokinetic parameters of MTX administered as monotherapy as well as in the combined therapy with simultaneous and prior administation of FU were investigated.The parameters were determined in the two-compartment open system on the basis of measurement of MTX levels in mice after i.p.administration of a single dose 20 mg/ kg of the dr
Abstract Neonatal brain is particularly vulnerable to pathological levels of bilirubin which elevates and overloads intracellular Ca2+, leading to neurotoxicity.However, how voltage-gated calcium channels (VGCCs) are functionally involved in excess calcium influx remains unknown.By performing voltage-clamp recordings from bushy cells in the ventral
Abstract Background Stories may be an effective tool to communicate with and influence patients because of their ability to engage the reader.The objective of this paper is to describe the development of a story-based intervention for delivery of health evidence to parents of children with croup for use in a randomized controlled trial.Methods A cr
Abstract Introduction: Pilot programs are integral to catalyzing and accelerating research at Clinical and Translational Science Award (CTSA) hubs.However, little has Griddles been published about the structure and operationalization of pilot programs or how they impact the translational research enterprise at CTSAs.The North Carolina Translational